• Senolytic
  • Senolytic
  • Senolytic
  • Senolytic
  • Senolytic
  • Senolytic
  • Senolytic
  • Senolytic
High Potency Cellular Renewal

Senolytic

Targets Aging Senescent Cells

$49.00
$49.00
Sale Sold out

Clear the cells that are aging you.

Senolytic supports your body's natural process of removing damaged, worn-out cells that accumulate with age — the ones that stop working but refuse to leave. Take once a month, for three days.

  • Senescence (clears out “zombie cells”)*
  • Cellular Renewal*
  • Tissue Rejuvenation*
  • High Potency 3-Day Protocol*
  • Monthly Cellular Detox*

    Cellular Clearance
    Fisetin and quercetin selectively push senescent "zombie cells" toward apoptosis — the natural cell death pathway they've learned to evade.

    Healthy Inflammatory Response
    Senescent cells release SASP: pro-inflammatory signaling molecules that damage neighboring healthy cells. Clearing them restores a cleaner cellular environment.

    Optimized Tissue Function & Microcirculation
    Senescent cells can disrupt healthy microcirculation. Supporting their clearance helps maintain healthy blood flow throughout tissues and organs.

    Bone & Muscle Resilience
    Senescent cells can accumulate in bone and muscle tissue with age, affecting the cellular environment. Supporting their clearance helps maintain healthy bone and muscle function.

    4 capsules once daily with food for three consecutive days, once a month. Same three days each month — the first of the month works well as a consistent anchor.

    1. Take 4 capsules with a meal
    2. Morning is best
    3. Every day for three days— don't skip.

    Fisetin
    The primary senolytic. Selectively pushes damaged cells toward natural cell death. 

    Quercetin
    Reinforces fisetin through complementary pathways. Lowers the threshold for damaged cells to clear naturally.

    Fenugreek
    Supports the oxidative environment during active clearance days.

    Bromelain
    Proteolytic enzyme. Helps mediate inflammation during the clearance pulse.

    Frequently Bought Together

    Cellular Architect

    Cellular Architect

    $69.95
    $69.95
    NMN + Resveratrol

    NMN + Resveratrol

    $59.95
    $59.95

    The Ultimate Monthly Reset for your Cellular Health

    Built to support your body's natural process of removing damaged cells (aka “zombie cells”) — the ones that accumulate with age, stop contributing, and drive chronic inflammation. By your mid-30s, your ability to clear them starts declining. This is the protocol that steps in.

    Four Ingredients. Each Chosen With Purpose.

    Two that clear cells. Two that protect the process.

    Fisetin

    Fisetin

    1400 mg

    The primary senolytic at a high dose. Selectively pushes damaged cells toward natural cell death.

    Quercetin

    Quercetin

    500 mg

    Reinforces fisetin. Lowers the threshold for damaged cells to clear.

    Fenugreek

    Fenugreek

    400 mg

    Supports the oxidative environment during clearance.

    Bromelain

    Bromelain

    300 mg (2400 GDU)

    Mediates inflammation during the clearance stage.

    Cellular Renewal • Tissue Rejuvenation • High Potency 3-Day Protocol •

    Remove What's Aging You

    Cellular changes happen gradually. This timeline shows what to expect as your cells adapt over time.

    Active Clearance

    Fisetin and quercetin get to work on damaged cells, supporting your body's natural process of clearing them out.

    How you'll feel

    Most people won't notice much yet — that's normal.

    Initial Response

    Your body continues clearing damaged cells, supporting a healthier cellular environment.

    How you'll feel

    Some people notice subtle improvements in recovery. Most still feel nothing — and that's fine.

    Tissue Response

    Inflammatory signaling begins to quiet. Some people notice subtle improvements in recovery, clarity, or energy.

    How you'll feel

    The changes are happening beneath the surface.

    Cumulative Benefit

    With each monthly cycle, the burden of damaged cells gradually reduces.

    How you'll feel

    Changes are cumulative and subtle — building at the cellular level long before they become something you'd notice day to day.

    Active Clearance
    Day 1–3

    Active Clearance

    Fisetin and quercetin get to work on damaged cells, supporting your body's natural process of clearing them out.

    How you'll feel

    Most people won't notice much yet — that's normal.

    Initial Response
    Day 4-7

    Initial Response

    Your body continues clearing damaged cells, supporting a healthier cellular environment.

    How you'll feel

    Some people notice subtle improvements in recovery. Most still feel nothing — and that's fine.

    Tissue Response
    Weeks 2-3

    Tissue Response

    Inflammatory signaling begins to quiet. Some people notice subtle improvements in recovery, clarity, or energy.

    How you'll feel

    The changes are happening beneath the surface.

    Cumulative Benefit
    Months 3-6+

    Cumulative Benefit

    With each monthly cycle, the burden of damaged cells gradually reduces.

    How you'll feel

    Changes are cumulative and subtle — building at the cellular level long before they become something you'd notice day to day.

    What Opens up When Damaged Cells Stop Getting in the Way

    • A healthier inflammatory response
      Fisetin is studied for its ability to support normal inflammatory signaling and cellular responses associated with aging.
    • Joints that keep you moving
      Fisetin has been studied for its potential role in supporting healthy joint and connective tissue function.
    • Bones that hold their ground
      Fisetin is being studied for its potential role in maintaining healthy bone tissue as we age.
    • Recovery that keeps pace with you
      Fisetin supports cellular pathways involved in the body's response to everyday physiological stress.
    • A mind that stays sharp with age
      Fisetin is being studied for its role in cellular pathways involved in healthy brain aging.

    Healthspan Demands a Higher Standard

    We provide an unconditional money-back guarantee on each order. If you're not satisfied for any reason, send us a message and we'll refund your money, no questions asked. We're that confident in what our Senolytic formula does — and in how we've built this formula.

    Over 60 years of manufacturing and science behind every capsule. cGMP certified. Manufactured in the USA. Every batch is held to the same standard we've kept for six decades. This is what it looks like when science comes first.

    Every batch is independently verified before it reaches you. Potency, purity, and contaminants — tested by an outside lab with no stake in the result. What's on the label is what's in the capsule. No exceptions.

    How We Compare

    Fisetin at research-level dose (1400 mg)
    Synergistic quercetin included
    Inflammation- support compounds
    Intermittent protocol guidance
    Third-party tested / cGMP
    Unconditional guarantee
    PGX Senolytic
    1400 mg
    500 mg
    Bromelain + Fenugreek
    Included
    NSF + NPN
    Unconditional
    Generic Fisetin
    Varies (100–500mg)
    Usually absent
    Varies
    Generic Quercetin
    Only
    Varies

    Frequently Asked Questions

    What are senolytics?

    Senolytics are compounds that support your body's natural process of clearing out damaged cells — the ones that stopped dividing but never died. They accumulate with age and quietly drive inflammation throughout your body. Senolytics are taken intermittently to help clear them.

    Why is the fisetin dose so high at 1400mg?

    Most brands use label doses — enough to look credible on packaging, not enough to match the research. 1400mg reflects what active human clinical trials actually use.

    Will I feel something during the 3 dosing days?

    Most people feel nothing, and that's typical. The changes are cellular, not symptomatic. Some users notice subtle shifts in energy or recovery in the days following. Measurable effects typically emerge after 3–6 months of repeated cycles.

    Can I take this alongside Urolithin A or NMN?

    Yes — and they're complementary by design. UA clears dysfunctional mitochondria inside cells. Senolytics clear entire dysfunctional cells. NMN fuels the repair that follows. Three distinct pathways. One coherent stack.

    Is this safe?

    Fisetin and quercetin are naturally occurring flavonoids with well-studied safety profiles. As with any supplement, individual response varies. Consult a healthcare professional if you take prescription medications, or are pregnant or nursing.

    Who should consider this?

    Anyone over 35 prioritizing cellular longevity, particularly those managing chronic inflammation, supporting joint or bone health, or building a longevity stack alongside mitochondrial support. Athletes also use it after heavy training cycles to address the cellular damage that accumulates under high physical load.

    What's your return policy?

    Unconditional money-back guarantee. Not satisfied for any reason — contact us for a full refund. No conditions.

    Is this product third-party tested?

    Yes. Every production run is tested by an independent third-party laboratory for potency, purity, and contaminants across all nine ingredients. Our manufacturing facility is NSF-registered, SQF-certified, and cGMP certified. Certificate of Analysis documentation is available upon request.

    Why only 3 days a month?

    The protocol matches the biology. Damaged cells accumulate over weeks — a short monthly clearance cycle is all that's needed. Three concentrated days clears what has accumulated. Then you wait for the next cycle. This isn't a daily supplement. It's a monthly protocol.